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PRK advantage, dry eye and new treatment

In the November 2014 issue of Review of Ophthalmology, a monthly publication of Jobson Medical Information, Jesper Hjorthal, MD, PhD, clinical professor at the University of Aarhus, Denmark and president of the European Eye Bank Association, reported the use of laser for surface ablation techniques. Dr. Hjorthal described his techniques for PRK (photorefractive keratectomy). PRK was the first type of laser eye surgery for vision correction and is the predecessor to the more popular LASIK procedure.

According to Dr. Hjorthal, PRK has advantages over LASIK in many instances that makes it more appealing. These are: 1. No surgical complications associated with creating a corneal flap. 2. No flap fold. 3. No risk of late dislocation of flap. 4. No epithelial growth. 5. No ectasia. 6. A shorter period of dry-eye symptoms.

In the same issue of Review of Ophthalmology, John Sheppard, MD, professor of ophthalmology, microbiology and molecular biology at Eastern Virginia Medical School and president of Virginia Eye Consultants in Norfolk, introduced lifitegrast, an emergent eye drops for treatment of dry eye.

Lifitegrast inhibits T-cell inflammation by preventing the binding of 2 cellular surface proteins LFA-1 and ICAM-1. Without the actual signal that caused by the binding of these two proteins, the ICAM-mediated T-cell response cannot occur. Lifitegrast is currently in FDA Phase III clinical trials.

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